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San Francisco 49ers vs. Seattle Seahawks NFL Week 4 Odds, Plays and Insights

Check out odds, plays and more for the San Francisco 49ers vs. Seattle Seahawks NFL Week 4 matchup on October 3, 2021.

Sep 26, 2021; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) is unable to make a catch in the end zone against the Green Bay Packers in the second quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports

NFC West opponents meet when the San Francisco 49ers (2-1) host the Seattle Seahawks (1-2) on Sunday, October 3, 2021 at Levi's Stadium. San Francisco is favored by 3 points. A total of 52 points has been set for this game.

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Odds for 49ers vs. Seahawks

Odds courtesy of SI Sportsbook.

Over/under insights

  • San Francisco and its opponents have combined for 52 points -- this matchup's over/under -- just two times this year.
  • Seattle has combined with its opponents to score more than 52 points in one game this season.
  • Sunday's total is 1.7 points lower than the two team's combined 53.7 points per game average.
  • This contest's over/under is one point above the 51 these two squads combine to allow per game this season.
  • 49ers games have an average total of 48.5 points this season, 3.5 fewer than Sunday's over/under.
  • The 52-point total for this game is 0.2 points below the 52.2 points per game average total in Seahawks games this season.

49ers stats and trends

  • San Francisco has one win against the spread in three games this year.
  • This season, the 49ers have just one ATS win in three games as a favorite of 3 points or more.
  • San Francisco's games this year have hit the over on two of three set point totals (66.7%).
  • This year, the 49ers rack up just 2.4 more points per game (28.7) than the Seahawks surrender (26.3).
  • San Francisco is 0-2 against the spread and 1-1 overall this season when the team records more than 26.3 points.
  • The 49ers average 91.6 fewer yards per game (348.7), than the Seahawks give up per contest (440.3).
  • The 49ers have turned the ball over three more times (5 total) than the Seahawks have forced a turnover (2) this season.
  • Click over to SISportsbook and find the latest spread, moneyline and total for San Francisco's matchup with the Seahawks.

Seahawks stats and trends

  • Seattle has one win against the spread in three games this year.
  • Seattle's games this season have gone over the total in one out of three opportunities (33.3%).
  • The Seahawks score just 0.3 more points per game (25) than the 49ers give up (24.7).
  • Seattle is 1-1 against the spread and 1-1 overall when the team records more than 24.7 points.
  • The Seahawks rack up 389 yards per game, just 18.7 more than the 370.3 the 49ers give up.
  • When Seattle picks up more than 370.3 yards, the team is 1-2 against the spread and 1-2 overall.
  • The Seahawks have one giveaway this season, while the 49ers have one takeaway.

Home and road insights

  • At home, the 49ers are winless ATS (0-1) as 3-point favorites or greater.
  • This season, 49ers home games average 50.5 points, 1.5 fewer than this contest's over/under (52).
  • The Seahawks are unbeaten ATS (1-0) as 3-point underdogs or more on the road.
  • Seahawks away games this season average 51.3 total points, 0.7 fewer than this outing's over/under (52).

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