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San Francisco 49ers vs. Indianapolis Colts NFL Week 7 Odds, Plays and Insights

Check out odds, plays and more for the San Francisco 49ers vs. Indianapolis Colts NFL Week 7 matchup on October 24, 2021.

Oct 10, 2021; Glendale, Arizona, USA; San Francisco 49ers head coach Kyle Shanahan walks off the field after the Arizona Cardinals defeated the 49ers 17-10 at State Farm Stadium. Mandatory Credit: Chris Coduto-USA TODAY Sports

The San Francisco 49ers (2-3) bring a three-game losing streak into a matchup against the Indianapolis Colts (2-4) on Sunday, October 24, 2021 at Levi's Stadium. San Francisco is favored by 4 points. The over/under is 44 in this game.

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Odds for 49ers vs. Colts

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Over/under insights

  • San Francisco has combined with its opponents to score more than 44 points in three of five games this season.
  • So far this season, 66.7% of Indianapolis' games (4/6) have had more combined points than Sunday's over/under of 44.
  • The combined points per game average of the two teams, 46.6, is 2.6 points greater than Sunday's over/under.
  • These two squads surrender a combined 45.6 points per game, 1.6 more than this contest's over/under.
  • The average total in 49ers games this season is 49.2, 5.2 points above Sunday's total of 44.
  • The 44-point total for this game is 2.1 points below the 46.1 points per game average total in Colts games this season.

49ers stats and trends

  • San Francisco has one win against the spread in five games this year.
  • This season, the 49ers are winless against the spread when entering a game as a favorite of 4 points or more.
  • San Francisco's games this year have hit the over two times in five opportunities (40%).
  • This year, the 49ers average just 1.6 more points per game (23.4) than the Colts give up (21.8).
  • When San Francisco records more than 21.8 points, it is 0-2 against the spread and 1-1 overall.
  • The 49ers rack up 368.2 yards per game, just 1.7 more than the 366.5 the Colts give up per outing.
  • San Francisco is 0-2 against the spread and 1-1 overall when the team piles up more than 366.5 yards.
  • The 49ers have turned the ball over seven times this season, five fewer than the Colts have forced (12).
  • Click over to SISportsbook and find the latest spread, moneyline and total for San Francisco's matchup with the Colts.

Colts stats and trends

  • In Indianapolis' six games this season, it has four wins against the spread.
  • The Colts have been underdogs by 4 points or more three times this season and have covered the spread twice.
  • Indianapolis' games this year have hit the over in 50% of its opportunities (three times in six games with a set point total).
  • The Colts average 23.2 points per game, comparable to the 23.8 the 49ers give up.
  • When Indianapolis puts up more than 23.8 points, it is 4-0 against the spread and 2-2 overall.
  • The Colts collect 37.7 more yards per game (367.5) than the 49ers give up per outing (329.8).
  • When Indianapolis picks up more than 329.8 yards, the team is 4-1 against the spread and 2-3 overall.
  • The Colts have turned the ball over five times this season, three more turnovers than the 49ers have forced (2).

Home and road insights

  • The average point total in 49ers home games this season is 51.3 points, 7.3 more than this matchup's over/under (44).
  • Indianapolis has two wins against the spread, and is 1-2 overall, away from home.
  • Indianapolis has hit the over twice in three road games this year.
  • Colts away games this season average 45.0 total points, 1.0 more than this outing's over/under (44).

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