New England Patriots vs. Buffalo Bills NFL Week 16 Odds, Plays and Insights

Dec 25, 2021

Check out odds, plays and more for the New England Patriots vs. Buffalo Bills NFL Week 16 matchup on December 26, 2021.

AFC East foes will clash in NFL Week 16 action when the New England Patriots (9-5) face the Buffalo Bills (8-6).

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Odds for Patriots vs. Bills

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New England and its opponents have combined to put up more than 43.5 points in seven of 14 games this season.
So far this season, 50% of Buffalo's games (7/14) have had more combined points than Sunday's over/under of 43.5.
Sunday's total is 10.8 points lower than the two team's combined 54.3 points per game average.
This contest's total is 9.9 points more than the 33.6 these two squads combine to allow per game this season.
Patriots games this season feature an average total of 44.7 points, a number 1.2 points higher than Sunday's over/under.
In 2021, games involving the Bills have averaged a total of 48.2 points, 4.7 more than the set total in this contest.

New England has played 14 games, with nine wins against the spread.
This season, the Patriots have an against the spread record of 6-3 in their nine games as a favorite of 2 points or more.
New England has gone over the point total in 42.9% of its opportunities this year (six times in 14 games with a set point total).
The Patriots score 8.8 more points per game (26.2) than the Bills give up (17.4).
New England is 7-2 against the spread and 8-1 overall in games when it puts up more than 17.4 points.
The Patriots rack up 60.0 more yards per game (347.9) than the Bills give up per outing (287.9).
When New England totals more than 287.9 yards, the team is 6-5 against the spread and 6-5 overall.
The Patriots have 18 giveaways this season, while the Bills have 27 takeaways.
Click over to SISportsbook and find the latest spread, moneyline and total for New England's matchup with the Bills.

Buffalo has eight wins against the spread in 14 games this year.
The Bills have covered the spread once this year when underdogs by 2 points or more (in two chances).
Buffalo's games this season have gone over the total in seven out of 14 opportunities (50%).
This year the Bills rack up 11.9 more points per game (28.1) than the Patriots surrender (16.2).
When Buffalo puts up more than 16.2 points, it is 8-2 against the spread and 8-2 overall.
The Bills average 70.4 more yards per game (377.9) than the Patriots allow (307.5).
When Buffalo piles up more than 307.5 yards, the team is 8-4 against the spread and 8-4 overall.
The Bills have turned the ball over 19 times, eight fewer times than the Patriots have forced turnovers (27).

At home this season, New England is 3-4 overall and 4-3 against the spread.
As 2-point favorites or more at home, the Patriots are 3-2 ATS.
This season, New England has gone over the total in four of seven home games.
This season, Patriots home games average 45.4 points, 1.9 more than this contest's over/under (43.5).
Buffalo is 4-3 overall, and 4-3 against the spread, on the road.
This season, as 2-point underdogs or more on the road, the Bills are 3-2 ATS.
This year, in four of seven road games Buffalo has hit the over.
Bills away games this season average 50.3 total points, 6.8 more than this outing's over/under (43.5).