Clemson vs. Louisville College Football Odds, Plays and Insights


Check out odds, insights and more in our betting preview for the Clemson Tigers vs. Louisville Cardinals college football matchup on November 6, 2021.

Oct 30, 2021; Clemson, South Carolina, USA; Clemson Tigers quarterback D.J. Uiagalelei (5) throws the ball against Florida State Seminoles defensive end Keir Thomas (4) during the fourth quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-USA TODAY Sports

The Clemson Tigers (5-3, 0-0 ACC) are favored by 4 points when they hit the road to play the Louisville Cardinals (4-4, 0-0 ACC) in ACC action on Saturday, November 6, 2021 at Cardinal Stadium. This game has an over/under of 46.5 points.

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Odds for Clemson vs. Louisville

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Over/Under Insights

  • Clemson's games this season have gone over 46.5 points three of eight times.
  • In 57.1% of Louisville's games this season (4/7), the teams combined to score more than Saturday's total of 46.5.
  • The two teams combine to score 50.7 points per game, 4.2 more than the over/under in this contest.
  • This contest's over/under is 4.1 points above the 42.4 these two squads combine to allow per game this season.
  • The average total in Tigers games this season is 49.0, 2.5 points more than Saturday's over/under of 46.5.
  • In 2021, games involving the Cardinals have averaged a total of 62.6 points, 16.1 more than the set total in this contest.

Clemson Stats and Trends

  • So far this year Clemson has one win against the spread.
  • The Tigers have covered the spread once this season when favored by 4 points or more (in six chances).
  • Clemson's games this year have gone over the point total two times in eight opportunities (25%).
  • The Tigers average 21.3 points per game, 5.8 fewer than the Cardinals give up per contest (27.1).
  • Clemson is 1-1 against the spread and 2-0 overall this season when the team records more than 27.1 points.
  • The Tigers rack up 87.1 fewer yards per game (328.3) than the Cardinals give up per contest (415.4).
  • Clemson is 0-2 against the spread and 2-0 overall when the team churns out more than 415.4 yards.
  • This year, the Tigers have turned the ball over 11 times, while the Cardinals have forced 11.
  • Find the latest spread and moneyline odds for Clemson at SISportsbook.

Louisville Stats and Trends

  • In Louisville's eight games this year, it has four wins against the spread.
  • The Cardinals have been underdogs by 4 points or more three times this season and have covered the spread twice.
  • Louisville's games this year have gone over the total in two out of seven opportunities (28.6%).
  • The Cardinals average 14.1 more points per game (29.4) than the Tigers allow (15.3).
  • Louisville is 4-2 against the spread and 4-3 overall in games when it puts up more than 15.3 points.
  • The Cardinals average 123.1 more yards per game (448.6) than the Tigers allow per contest (325.5).
  • Louisville is 4-3 against the spread and 4-4 overall when the team amasses over 325.5 yards.
  • The Cardinals have turned the ball over one more time (12 total) than the Tigers have forced a turnover (11) this season.
  • Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.

Season Stats