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Arizona Cardinals vs. San Francisco 49ers NFL Week 5 Odds, Plays and Insights

Check out odds, plays and more for the Arizona Cardinals vs. San Francisco 49ers NFL Week 5 matchup on October 10, 2021.

Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals wide receiver A.J. Green (18) runs the ball against the Los Angeles Rams during the second half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports

Oddsmakers give the Arizona Cardinals (4-0) a decent chance to keep their four-game winning streak alive, as they are favored by 5 points in a matchup against the San Francisco 49ers (2-2) on Sunday, October 10, 2021 at State Farm Stadium. The over/under is 48.5 for this game.

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Odds for Cardinals vs. 49ers

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Over/under insights

  • Arizona and its opponents have gone over 48.5 points in all four games this season.
  • So far this season, 75% of San Francisco's games (3/4) have had more combined points than Sunday's over/under of 48.5.
  • Sunday's over/under is 13.3 points lower than the two team's combined 61.8 points per game average.
  • These two squads combine to allow 46.8 points per game, 1.7 fewer than this contest's over/under.
  • The average total in Cardinals games this season is 52.4, 3.9 points above Sunday's total of 48.5.
  • In 2020, games involving the 49ers have averaged a total of 49.4 points, 0.9 more than the set over/under in this contest.

Cardinals stats and trends

  • Arizona has played four games, with three wins against the spread.
  • The Cardinals have been favored by 5 points or more once this season and covered the spread.
  • Arizona's games this year have eclipsed the over/under two times in four opportunities (50%).
  • This year, the Cardinals put up 9.5 more points per game (35) than the 49ers allow (25.5).
  • Arizona is 3-1 against the spread and 4-0 overall in games when it records more than 25.5 points.
  • The Cardinals average 103.7 more yards per game (440.5) than the 49ers give up per contest (336.8).
  • In games that Arizona picks up over 336.8 yards, the team is 3-1 against the spread and 4-0 overall.
  • This year, the Cardinals have turned the ball over four times, three more than the 49ers' takeaways (1).
  • Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the 49ers.

49ers stats and trends

  • Thus far this season San Francisco has one win against the spread.
  • San Francisco's games this season have hit the over on two of four set point totals (50%).
  • The 49ers rack up 26.8 points per game, 5.5 more than the Cardinals allow (21.3).
  • When San Francisco records more than 21.3 points, it is 0-2 against the spread and 1-1 overall.
  • The 49ers rack up only 18.5 more yards per game (375.8) than the Cardinals allow per outing (357.3).
  • San Francisco is 0-2 against the spread and 1-1 overall when the team picks up more than 357.3 yards.
  • The 49ers have turned the ball over six times, three fewer times than the Cardinals have forced turnovers (9).

Home and road insights

  • Cardinals home games this season average 50.5 total points, 2.0 more than this outing's over/under (48.5).
  • On the road, the 49ers are winless ATS (0-1) as 5-point underdogs or more.
  • 49ers away games this season average 47.5 total points, 1.0 fewer than this contest's over/under (48.5).

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