Arizona Cardinals vs. Indianapolis Colts NFL Week 16 Odds, Plays and Insights

Dec 25, 2021

Check out odds, plays and more for the Arizona Cardinals vs. Indianapolis Colts NFL Week 16 matchup on December 25, 2021.

It'll be the Arizona Cardinals (10-4) versus the Indianapolis Colts (8-6) in NFL Week 16 action.

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Odds for Cardinals vs. Colts

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Arizona has combined with its opponents to put up more than 48.5 points in seven of 14 games this season.
Indianapolis and its opponents have combined to score more than 48.5 points in six of 14 games this season.
The combined points per game average of the two teams, 55.4, is 6.9 points more than Saturday's over/under.
The 41.7 combined points per game that these two squads have allowed this season are 6.8 fewer than the 48.5 over/under in this contest.
The average total in Cardinals games this season is 48.4, 0.1 points fewer than Saturday's over/under of 48.5.
The 47.0 PPG average total in Colts games this season is 1.5 points fewer than this game's over/under.

In Arizona's 14 games this year, it has nine wins against the spread.
The Cardinals have been favored by 2.5 points or more nine times this season and are 4-5 ATS in those matchups.
Arizona's games this year have gone over the point total in 50% of its opportunities (seven times in 14 games with a set point total).
The Cardinals put up 5.6 more points per game (27.0) than the Colts give up (21.4).
Arizona is 8-2 against the spread and 9-1 overall in games when it scores more than 21.4 points.
The Cardinals average 376.4 yards per game, 32.7 more yards than the 343.7 the Colts allow per contest.
In games that Arizona picks up over 343.7 yards, the team is 7-3 against the spread and 8-2 overall.
This year, the Cardinals have 14 turnovers, 17 fewer than the Colts have takeaways (31).
Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the Colts.

Against the spread, Indianapolis is 9-5-0 this season.
The Colts are 5-3 ATS when underdogs by 2.5 points or more this season.
Indianapolis' games this season have hit the over eight times in 14 opportunities (57.1%).
The Colts score 28.4 points per game, 8.1 more than the Cardinals give up (20.3).
Indianapolis is 9-3 against the spread and 8-4 overall when the team scores more than 20.3 points.
The Colts average 361.4 yards per game, 38.6 more yards than the 322.8 the Cardinals give up.
When Indianapolis totals more than 322.8 yards, the team is 7-2 against the spread and 5-4 overall.
This year the Colts have 17 turnovers, seven fewer than the Cardinals have takeaways (24).

At home this season, Arizona has two wins against the spread and is 3-3 overall.
The Cardinals have two wins ATS (2-4) as 2.5-point favorites or more at home.
In three of six home games this season, Arizona has gone over the total.
This season, Cardinals home games average 48.3 points, 0.2 fewer than this outing's over/under (48.5).
On the road, Indianapolis is 4-2 overall and 5-1 against the spread.
Away from home, the Colts are unbeaten ATS (1-0) as 2.5-point underdogs or more.
This season, in six away games, Indianapolis has hit the over four times.
Colts away games this season average 45.6 total points, 2.9 fewer than this contest's over/under (48.5).