Arizona Cardinals vs. Indianapolis Colts NFL Week 16 Odds, Plays and Insights

Dec 24, 2021

Check out odds, plays and more for the Arizona Cardinals vs. Indianapolis Colts NFL Week 16 matchup on December 25, 2021.

The Arizona Cardinals (10-4) will battle the Indianapolis Colts (8-6) in Week 16 of the NFL season.

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Odds for Cardinals vs. Colts

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Arizona and its opponents have combined to score more than 49 points in seven of 14 games this season.
Indianapolis' games have gone over 49 points in six of 14 chances this season.
Saturday's over/under is 6.4 points lower than the two team's combined 55.4 points per game average.
This contest's over/under is 7.3 points more than the 41.7 these two squads combine to allow per game this season.
Cardinals games have an average total of 48.4 points this season, 0.6 fewer than Saturday's over/under.
In 2021, games involving the Colts have averaged a total of 47.0 points, 2.0 fewer than this game's set over/under.

Against the spread, Arizona is 9-5-0 this season.
This season, the Cardinals have an ATS record of 4-5 in their nine games as a favorite of 2 points or more.
Arizona's games this year have gone over the total in seven out of 14 opportunities (50%).
This year, the Cardinals average 5.6 more points per game (27.0) than the Colts allow (21.4).
When Arizona scores more than 21.4 points, it is 8-2 against the spread and 9-1 overall.
The Cardinals collect 32.7 more yards per game (376.4) than the Colts give up per outing (343.7).
Arizona is 7-3 against the spread and 8-2 overall when the team picks up more than 343.7 yards.
This year, the Cardinals have 14 turnovers, 17 fewer than the Colts have takeaways (31).
Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the Colts.

Indianapolis has nine wins against the spread in 14 games this season.
The Colts have an against the spread record of 5-3 in their eight games as an underdog of 2 points or more this season.
Indianapolis' games this season have hit the over on eight of 14 set point totals (57.1%).
The Colts rack up 28.4 points per game, 8.1 more than the Cardinals allow (20.3).
Indianapolis is 9-3 against the spread and 8-4 overall in games when it records more than 20.3 points.
The Colts collect 361.4 yards per game, 38.6 more yards than the 322.8 the Cardinals allow.
When Indianapolis churns out more than 322.8 yards, the team is 7-2 against the spread and 5-4 overall.
This year the Colts have 17 turnovers, seven fewer than the Cardinals have takeaways (24).

At home this season, Arizona has two wins against the spread and is 3-3 overall.
At home, as 2-point favorites or greater, the Cardinals have two wins ATS (2-4).
In six games at home this year, Arizona has hit the over three times.
The average total in Cardinals home games this season is 48.3 points, 0.7 fewer than this contest's over/under (49).
Indianapolis is 4-2 overall, and 5-1 against the spread, on the road.
The Colts are unbeaten ATS (1-0) on the road as 2-point underdogs or more.
In four of six road games this year, Indianapolis has gone over the total.
Colts away games this season average 45.6 total points, 3.4 fewer than this contest's over/under (49).