Arizona Cardinals vs. Indianapolis Colts NFL Week 16 Odds, Plays and Insights

Dec 23, 2021

Check out odds, plays and more for the Arizona Cardinals vs. Indianapolis Colts NFL Week 16 matchup on December 25, 2021.

The Arizona Cardinals (10-4) and Indianapolis Colts (8-6) will battle in Week 16 of the NFL season.

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Odds for Cardinals vs. Colts

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Arizona and its opponents have gone over the current 48.5-point total in seven of 14 games this season.
Indianapolis' games have gone over 48.5 points in six of 14 chances this season.
Saturday's over/under is 6.9 points lower than the two team's combined 55.4 points per game average.
The 41.7 combined points per game that these two squads have allowed this season are 6.8 fewer than the 48.5 total in this contest.
Cardinals games have an average total of 48.4 points this season, 0.1 fewer than Saturday's over/under.
The 47.0 PPG average total in Colts games this season is 1.5 points fewer than this game's over/under.

Arizona is 9-5-0 against the spread this year.
The Cardinals have been favored by 1.5 points or more nine times this season and are 4-5 ATS in those matchups.
Arizona's games this year have gone over the total in seven out of 14 opportunities (50%).
This year, the Cardinals put up 5.6 more points per game (27.0) than the Colts give up (21.4).
Arizona is 8-2 against the spread and 9-1 overall in games when it scores more than 21.4 points.
The Cardinals collect 32.7 more yards per game (376.4) than the Colts allow per outing (343.7).
When Arizona piles up more than 343.7 yards, the team is 7-3 against the spread and 8-2 overall.
This year, the Cardinals have 14 turnovers, 17 fewer than the Colts have takeaways (31).
Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the Colts.

Indianapolis is 9-5-0 against the spread this season.
This season, the Colts have an ATS record of 5-3 in their eight games as an underdog of 1.5 points or more.
Indianapolis' games this year have hit the over on eight of 14 set point totals (57.1%).
This year the Colts rack up 8.1 more points per game (28.4) than the Cardinals give up (20.3).
When Indianapolis puts up more than 20.3 points, it is 9-3 against the spread and 8-4 overall.
The Colts rack up 38.6 more yards per game (361.4) than the Cardinals give up (322.8).
Indianapolis is 7-2 against the spread and 5-4 overall when the team churns out over 322.8 yards.
The Colts have turned the ball over 17 times, seven fewer times than the Cardinals have forced turnovers (24).

At home this season, Arizona has two wins against the spread and is 3-3 overall.
The Cardinals have two wins ATS (2-4) as 1.5-point favorites or more at home.
In three of six games at home this season, Arizona has hit the over.
Cardinals home games this season average 48.3 total points, 0.2 fewer than this outing's over/under (48.5).
Indianapolis is 4-2 overall, and 5-1 against the spread, on the road.
The Colts are unbeaten ATS (1-0) away from home as 1.5-point underdogs or more.
Indianapolis has hit the over in four of six road games this season.
The average total in Colts away games this season is 45.6 points, 2.9 fewer than this matchup's over/under (48.5).