Arizona Cardinals vs. Indianapolis Colts NFL Week 16 Odds, Plays and Insights

Dec 22, 2021

Check out odds, plays and more for the Arizona Cardinals vs. Indianapolis Colts NFL Week 16 matchup on December 25, 2021.

The Arizona Cardinals (10-4) and Indianapolis Colts (8-6) will battle in a Week 16 NFL matchup.

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Odds for Cardinals vs. Colts

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Arizona and its opponents have gone over the current 49-point total in seven of 14 games (50%) this season.
So far this season, 42.9% of Indianapolis' games (6/14) have had more combined points than Saturday's over/under of 49.
Saturday's total is 6.4 points lower than the two team's combined 55.4 points per game average.
The 41.7 combined points per game that these two squads have allowed this season are 7.3 fewer than the 49 total in this contest.
The average total in Cardinals games this season is 48.4, 0.6 points fewer than Saturday's over/under of 49.
In 2021, games involving the Colts have averaged a total of 47.0 points, 2.0 fewer than this game's set over/under.

In Arizona's 14 games this season, it has nine wins against the spread.
The Cardinals have been favored by 1 point or more nine times this season and are 4-5 ATS in those matchups.
Arizona's games this year have gone over the point total in 50% of its opportunities (seven times in 14 games with a set point total).
The Cardinals score 5.6 more points per game (27.0) than the Colts allow (21.4).
When Arizona puts up more than 21.4 points, it is 8-2 against the spread and 9-1 overall.
The Cardinals rack up 376.4 yards per game, 32.7 more yards than the 343.7 the Colts give up per matchup.
When Arizona picks up more than 343.7 yards, the team is 7-3 against the spread and 8-2 overall.
The Cardinals have turned the ball over 14 times this season, 17 fewer than the Colts have forced (31).
Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the Colts.

Indianapolis is 9-5-0 against the spread this year.
The Colts are 5-3 ATS when underdogs by 1 point or more this year.
Indianapolis' games this season have hit the over in 57.1% of its opportunities (eight times in 14 games with a set point total).
The Colts put up 28.4 points per game, 8.1 more than the Cardinals allow (20.3).
When Indianapolis scores more than 20.3 points, it is 9-3 against the spread and 8-4 overall.
The Colts collect 38.6 more yards per game (361.4) than the Cardinals give up per contest (322.8).
Indianapolis is 7-2 against the spread and 5-4 overall when the team piles up more than 322.8 yards.
The Colts have 17 giveaways this season, while the Cardinals have 24 takeaways.

Arizona has covered the spread twice at home, and is 3-3 overall there, this season.
At home, as 1-point favorites or greater, the Cardinals have two wins ATS (2-4).
In three of six games at home this year, Arizona has gone over the total.
This season, Cardinals home games average 48.3 points, 0.7 fewer than this matchup's over/under (49).
In away games, Indianapolis is 4-2 overall and 5-1 against the spread.
The Colts are unbeaten ATS (1-0) as 1-point underdogs or more on the road.
In four of six road games this year, Indianapolis has gone over the total.
The average total in Colts away games this season is 45.6 points, 3.4 fewer than this matchup's over/under (49).