Perry Baker was the hero as hosts USA secured a semi-final spot in the Las Vegas Sevens following a 17-12 victory over England.
The unbeaten US side won thanks to three tries from Baker, with Simon Amor’s men unable to handle the sheer pace of the 2017 Player of the Year.
They join series leaders South Africa, who also moved into the last four on Saturday after beating Australia 29-17.
Playing at the packed 40,000-seat Sam Boyd Stadium, the Blitzboks advanced to Sunday's semi-final with a strong second half showing after the game was tied 12-all at half-time.
The South Africans will take on Argentina in the last four after they defeated Kenya 17-12.
In the other quarter-final, Jerry Tuwai scored the winning try almost two minutes after the final siren as Olympic champions Fiji pipped New Zealand 14-10.
South Africa lead the series with 77 points after four rounds, with New Zealand (69), Fiji (62) and Australia (60) making up the top four. The Americans are in seventh place on 36 points.
Day two results:
Cup quarter-finals:
South Africa 29-17 Australia
Argentina 17-12 Kenya
USA 17-12 England
Fiji 14-10 New Zealand
Challenge Trophy quarter-finals:
Canada 21-14 Spain
Samoa 19-21 Wales
Scotland 24-12 Russia
France 40-7 Uruguay
Pool stages:
South Africa 24-19 England
Canada 21-19 Wales
Australia 24-7 Samoa
USA 28-17 Spain
Fiji 14-17 Kenya
France 31-7 Russia
New Zealand 26-17 Scotland
Argentina 31-0 Uruguay
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