Captain Dylan Hartley has returned to the England side for the visit of Ireland after recovering from injury, while Elliot Daly is also in the XV.
Tighthead prop Kyle Sinckler makes his first start of the campaign with stalwart Dan Cole dropping to the bench.
Saracens lock George Kruis will partner Maro Itoje in the second-row while James Haskell will start at openside flanker with Chris Robshaw moving to the blindside.
Saracens club mates Richard Wigglesworth and Owen Farrell will start as the half-back pairing. Ben Te’o moves to inside centre with Jonathan Joseph recalled at outside centre.
Don Armand is named among the replacements in what is otherwise an experienced bench for England.
“We can’t wait to get back to Twickenham and play there. We have had a couple of tough games on the road and to get back and play in front of our 24th man will be exciting for the players and they will be looking forward to putting in a good performance,” said head coach Eddie Jones.
“Ireland is a very good team. We have seen in every game the physical contest has been quite enormous so we have to meet that physical challenge and then play smart tactically.”
England: 15 Anthony Watson, 14 Jonny May, 13 Jonathan Joseph, 12 Ben Te’o, 11 Elliot Daly, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Sam Simmonds, 7 James Haskell, 6 Chris Robshaw, 5 George Kruis, 4 Maro Itoje, 3 Kyle Sinckler, 2 Dylan Hartley (c), 1 Mako Vunipola
Replacements: 16 Jamie George, 17 Joe Marler, 18 Dan Cole, 19 Joe Launchbury, 20 Don Armand, 21 Danny Care, 22 George Ford, 23 Mike Brown
Date: Saturday, March 17
Venue: Twickenham
Kick-off: 14:45 GMT
Referee: Angus Gardner (Australia)
Assistant Referees: Jaco Peyper (South Africa), Marius van der Westhuizen (South Africa)
TMO: Ben Skeen (New Zealand)
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