CLAUDE PUEL’S men were unlucky not to come away with a point in the San Siro and can gain revenge at St Mary’s.
Charlie Austin’s European form – two goals in two games – should stand the Saints in good stead against Inter, who today sacked manager Frank de Boer.
Frank de Boer has been sacked as Inter Milan managerEPA
And the side could be bolstered further by the return of Jay Rodriguez and Shane Long.
What time is Southampton vs Inter Milan, what channel is it on and what are the latest odds?
Rodriguez suffered a concussion in the 1-0 EFL Cup win over Sunderland and Long has been nursing a hamstring injury.
The Ireland star has not played since the defeat in Italy at the end of last month.
Southampton were hardly a disgrace in the 2-0 loss to Chelsea at home last weekend but looked to lack a little firepower up top.
That could change against Inter, who currently sit bottom of their group.
Jay Rodriguez was injured in a clash of heads but could return to actionGetty Images
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Moreover, Oriel Romeu is desperate to avoid back-to-back home defeats.
He said: "We have to come back now. We don't want to lose two in a row.
"The season is very long and we need to come back. We have been very good recently, and the feelings are bad today because we have lost.
"We are being honest with ourselves, but we need to look forward and we need to be proud as well."
As for Inter Milan, Brazilian sensation Gabriel Barbosa may come back into the fold after being left out at the squad that lost to Sampdoria
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