For Joshua, 27, from nearby Watford, this is just the 19th professional fight on his CV.
Yet he faces the formidable Ukrainian Klitschko, 41, whose nine-year, seven-month reign as heavyweight world champion, featured 18 successful defences on the bounce.
Anthony Joshua has been on a five-point plan designed to dismantle KlitschkoNews Group Newspapers LtdAnthony Joshua faces a massive step up in class when he takes on UkrainianNews Group Newspapers Ltd
That is second only to American legend Joe Louis, who was champion for more than 11 years and defended his belts 25 times.
But, in conjunction with Great Britain amateur coach Rob McCracken, Joshua has devised the masterplan which he feels will KO Klitschko and maintain his unbeaten professional record.
Joshua explains:
1. With someone like Klitschko, you have to stay off the line at all times. Use little head movements to slip the Ukrainian’s attacks.
2. Speed is key. I am 14 years younger than my opponent and need to take full advantage of being younger and faster than a man who has been out of the ring for 17 months.
3. Put your combos together and if you are that quick — bang, bang, bang — you will meet Klitschko’s attacks and stop them in their tracks.
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4. Klitschko is a man who is quite tall and who uses his height well. He dips his chin rather than his whole torso.
He likes to stay relaxed and manoeuvre his opponent with the left hand, like a smokescreen. Don’t let him get you where he wants you.
5. He keeps you at bay. Stay there, stay there, and then bang, he hopes for the knockout. But in his last fight, against Tyson Fury, Klitschko landed only 52 punches in 12 rounds and that eventually cost him.
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