Manchester United’s clash against St Etienne has been moved to WednesdayGetty Images
As Lyon finished higher in Ligue 1 last season, they have priority over the date of fixture.
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The first-leg will be held at Old Trafford on Thursday 16 February before the reverse fixture will take place six days later on Wednesday 22 at the Stade Geoffroy-Guichard.
It may also mean the Manchester derby, scheduled for Saturday 22nd, could remain on the same date instead of being rescheduled to the Sunday.
Saint Etienne are undefeated in Europe this seasonGetty Images
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Meanwhile United fans have taken to Twitter to mock their own run in the tournament by claiming a European match on a Wednesday is 'basically Champions League'.
One supporter said: "Zlatan doesn't do Thursday nights anymore"
St Etienne finished sixth in Ligue 1 last season but United boss Jose Mourinho will be confident his side can beat the French outfit and head into the round of 16.
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