Charlie Austin faces four months on the sidelinesGetty Images
Southampton boss Claude Puel said: "Normally that means surgery and between three and four months.
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"Of course it's difficult to play without Charlie because he has scored a lot of goals for us.
"We will have to look to other players, such as Jay Rodriguez.
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"It's important all the players take up the challenge of being without Charlie."
Austin is Southampton's top scorer with nine goals, six of them in the Premier League.
Austin had his shoulder popped back in and was keen to play onAP:Associated PressThe former QPR striker was seen screaming in agony on the floorPA:Press AssociationSofiane Boufal celebrates scoring against Boro with boss Claude PuelReuters
But the injury he suffered to his right shoulder on Thursday is set to keep him on the sidelines for some time.
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